CACNB4 antibody (AA 401-520)

Catalog No. ABIN6137821

Product Details anti-CACNB4 Antibody

Target: CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))

Binding Specificity: AA 401-520

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNB4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ATHTTSSTPM TPLLGRNLGS TALSPYPTAI SGLQSQRMRH SNHSTENSPI ERRSLMTSDE NYHNERARKS RNRLSSSSQH SRDHYPLVEE DYPDSYQDTY KPHRNRGSPG GYSHDSRHRL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 401-520 of human CACNB4 (NP_000717.2).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CACNB4

Target: CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))

Alternative Name: CACNB4 (CACNB4 Products)

Background: This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene.,CACNB4,CAB4,CACNLB4,EA5,EIG9,EJM,EJM4,EJM6,Signal Transduction,Neuroscience,Calcium Signaling,CACNB4

Molecular Weight: 51 kDa/54 kDa/56 kDa/58 kDa

Gene ID: 785

UniProt: O00305

Pathways: cAMP Metabolic Process, Skeletal Muscle Fiber Development