CAPN10 antibody (AA 1-230)

Catalog No. ABIN6137913

This Rabbit Polyclonal antibody specifically detects CAPN10 in WB. It exhibits reactivity toward Human.

Quick Overview for CAPN10 antibody (AA 1-230) (ABIN6137913)

Target: CAPN10 (Calpain 10 (CAPN10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAPN10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CAPN10 Antibody

Binding Specificity: AA 1-230

Sequence: MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC ATPRLFPDDP REGQVKQGLL GDCWFLCACA ALQKSRHLLD QVIPPGQPSW ADQEYRGSFT CRIWQFGRWV EVTTDDRLPC LAGRLCFSRC QREDVFWLPL LEKVYAKVHG SYEHLWAGQV ADALVDLTGG LAERWNLKGV AGSGGQQDRP GRWEHRTCRQ LLHLKDQCLI SCCVLSPRAG

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CAPN10 (NP_075571.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:4000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CAPN10

Target: CAPN10 (Calpain 10 (CAPN10))

Alternative Name: CAPN10

Background: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation, domain II, the protease domain, domain III, a linker domain of unknown function, and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.,CAPN10,CANP10,NIDDM1,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Endocrine & Metabolism,Endocrine and metabolic diseases,Metabolic disorders,Neuroscience,Calcium Signaling,CAPN10

Molecular Weight: 15 kDa/29 kDa/49 kDa/57 kDa/60 kDa/74 kDa

Gene ID: 11132

UniProt: Q9HC96

Pathways: Positive Regulation of Peptide Hormone Secretion