CENPJ antibody (AA 1069-1338)

Catalog No. ABIN6138409

The Rabbit Polyclonal anti-CENPJ antibody has been validated for WB. It is suitable to detect CENPJ in samples from Human.

Quick Overview for CENPJ antibody (AA 1069-1338) (ABIN6138409)

Target: CENPJ (Centromere Protein J (CENPJ))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CENPJ antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CENPJ Antibody

Binding Specificity: AA 1069-1338

Sequence: DKLANTSVRF QNSQISSGTQ VEKYKKNYLP MQGNPPRRSK SAPPRDLGNL DKGQAASPRE PLEPLNFPDP EYKEEEEDQD IQGEISHPDG KVEKVYKNGC RVILFPNGTR KEVSADGKTI TVTFFNGDVK QVMPDQRVIY YYAAAQTTHT TYPEGLEVLH FSSGQIEKHY PDGRKEITFP DQTVKNLFPD GQEESIFPDG TIVRVQRDGN KLIEFNNGQR ELHTAQFKRR EYPDGTVKTV YANGHQETKY RSGRIRVKDK EGNVLMDTEL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1069-1338 of human CENPJ (NP_060921.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CENPJ

Target: CENPJ (Centromere Protein J (CENPJ))

Alternative Name: CENPJ

Background: This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene.,CENPJ,BM032,CENP-J,CPAP,LAP,LIP1,MCPH6,SASS4,SCKL4,Sas-4,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Centromere,CENPJ

Molecular Weight: 124 kDa/153 kDa

Gene ID: 55835

UniProt: Q9HC77

Pathways: M Phase