Complement Factor H antibody (AA 270-445)

Catalog No. ABIN6138452

The Rabbit Polyclonal anti-Complement Factor H antibody has been validated for WB. It is suitable to detect Complement Factor H in samples from Human.

Quick Overview for Complement Factor H antibody (AA 270-445) (ABIN6138452)

Target: Complement Factor H (CFH)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor H antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Complement Factor H Antibody

Binding Specificity: AA 270-445

Sequence: PYIPNGDYSP LRIKHRTGDE ITYQCRNGFY PATRGNTAKC TSTGWIPAPR CTLKPCDYPD IKHGGLYHEN MRRPYFPVAV GKYYSYYCDE HFETPSGSYW DHIHCTQDGW SPAVPCLRKC YFPYLENGYN QNHGRKFVQG KSIDVACHPG YALPKAQTTV TCMENGWSPT PRCIRV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 270-445 of human Complement factor H (NP_001014975.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Complement Factor H

Target: Complement Factor H (CFH)

Alternative Name: CFH

Background: This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.,CFH,AHUS1,AMBP1,ARMD4,ARMS1,CFHL3,FH,FHL1,HF,HF1,HF2,HUS,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,CFH

Molecular Weight: 51 kDa/139 kDa

Gene ID: 3075

UniProt: P08603

Pathways: Complement System, Cellular Response to Molecule of Bacterial Origin