Claudin 16 antibody (AA 50-150)

Catalog No. ABIN6138679

The Rabbit Polyclonal anti-Claudin 16 antibody has been validated for WB. It is suitable to detect Claudin 16 in samples from Human.

Quick Overview for Claudin 16 antibody (AA 50-150) (ABIN6138679)

Target: Claudin 16 (CLDN16)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 16 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Claudin 16 Antibody

Binding Specificity: AA 50-150

Sequence: HLSGARAGVC PCCHPDGLLA TMRDLLQYIA CFFAFFSAGF LIVATWTDCW MVNADDSLEV STKCRGLWWE CVTNAFDGIR TCDEYDSILA EHPLKLVVTR A

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CLDN16 (NP_006571.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Claudin 16

Target: Claudin 16 (CLDN16)

Alternative Name: CLDN16

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.,CLDN16,HOMG3,PCLN1,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Tight Junctions,Cytoskeleton,CLDN16

Molecular Weight: 33 kDa

Gene ID: 10686

UniProt: Q9Y5I7

Pathways: Hepatitis C