COL1A2 antibody (AA 500-600)

Catalog No. ABIN6138839

This anti-COL1A2 antibody is a Rabbit Polyclonal antibody detecting COL1A2 in WB, IHC and IF. Suitable for Human. This Primary Antibody has been cited in 3+ publications.

Quick Overview for COL1A2 antibody (AA 500-600) (ABIN6138839)

Target: COL1A2 (Collagen, Type I, alpha 2 (COL1A2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL1A2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-COL1A2 Antibody

Binding Specificity: AA 500-600

Sequence: PTGDPGKNGD KGHAGLAGAR GAPGPDGNNG AQGPPGPQGV QGGKGEQGPP GPPGFQGLPG PSGPAGEVGK PGERGLHGEF GLPGPAGPRG ERGPPGESGA A

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 500-600 of human Collagen I/COL1A2 (NP_000080.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:25 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-COL1A2 antibody (ABIN6138839)

Jiang, He, Zhu, Liang, Wang, Lu, Ren, Yi, Xiao, Wang: "Endoplasmic reticulum stress-dependent ROS production mediates synovial myofibroblastic differentiation in the immobilization-induced rat knee joint contracture model." in: Experimental cell research, Vol. 369, Issue 2, pp. 325-334, (2018) (PubMed).

Yu, Zheng, Yang, Fei, Wang, Hou, Sun, Shen: "N-AC-l-Leu-PEI-mediated miR-34a delivery improves osteogenic differentiation under orthodontic force." in: Oncotarget, Vol. 8, Issue 66, pp. 110460-110473, (2017) (PubMed).

Li, Wan, Zhang, Li, Han: "Quantitative proteomic analysis and comparison of two bone marrow stromal cell lines using the SILAC method." in: Experimental hematology, Vol. 44, Issue 11, pp. 1059-1071, (2017) (PubMed).

Target Details for COL1A2

Target: COL1A2 (Collagen, Type I, alpha 2 (COL1A2))

Alternative Name: COL1A2

Background: This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.,COL1A2,OI4,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Collagen,Growth factor,Stem Cells,Mesenchymal Stem Cells,COL1A2

Molecular Weight: 129 kDa

Gene ID: 1278

UniProt: P08123