Exportin 2 antibody (AA 50-150)

Catalog No. ABIN6139091

This Rabbit Polyclonal antibody specifically detects Exportin 2 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Exportin 2 antibody (AA 50-150) (ABIN6139091)

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Exportin 2 Antibody

Binding Specificity: AA 50-150

Sequence: LEKSQDNVIK VCASVTFKNY IKRNWRIVED EPNKICEADR VAIKANIVHL MLSSPEQIQK QLSDAISIIG REDFPQKWPD LLTEMVNRFQ SGDFHVINGV L

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Exportin 2 (XPO2) (NP_001243064.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:100 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Alternative Name: CSE1L

Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.,CSE1L,CAS,CSE1,XPO2,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,CSE1L

Molecular Weight: 22 kDa/103 kDa/107 kDa/110 kDa

Gene ID: 1434

UniProt: P55060

Pathways: Protein targeting to Nucleus