CYP46A1 antibody (AA 24-280)

Catalog No. ABIN6139358

Product Details anti-CYP46A1 Antibody

Target: CYP46A1 (Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1))

Binding Specificity: AA 24-280

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP46A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: HRARSRYEHI PGPPRPSFLL GHLPCFWKKD EVGGRVLQDV FLDWAKKYGP VVRVNVFHKT SVIVTSPESV KKFLMSTKYN KDSKMYRALQ TVFGERLFGQ GLVSECNYER WHKQRRVIDL AFSRSSLVSL METFNEKAEQ LVEILEAKAD GQTPVSMQDM LTYTAMDILA KAAFGMETSM LLGAQKPLSQ AVKLMLEGIT ASRNTLAKFL PGKRKQLREV RESIRFLRQV GRDWVQRRRE ALKRGEEVPA DILTQIL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-280 of human CYP46A1 (NP_006659.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CYP46A1

Target: CYP46A1 (Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1))

Alternative Name: CYP46A1 (CYP46A1 Products)

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.,CYP46A1,CP46,CYP46,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Drug metabolism,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,CYP46A1

Molecular Weight: 38 kDa/45 kDa/56 kDa

Gene ID: 10858

UniProt: Q9Y6A2