CYP46A1 Products
(Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1))
Categories
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008].
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Featured CYP46A1 Categories
CYP46A1 Antibodies
High quality antibodies with extensive validation data.
CYP46A1 ELISA Kits
Reliable ELISA kits for a wide range of species.
CYP46A1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CYP46A1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IP
Validations
- (3)
Cat. No.
ABIN524256
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7190421
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rat
Application
WB
Validations
- (3)
Cat. No.
ABIN2773829
Quantity
100 μL
Datasheet
Datasheet
Recommended CYP46A1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955263
Quantity
96 tests
Datasheet
Datasheet
Recommended CYP46A1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351000
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3119551
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3120164
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CYP46A1 products
: "24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure." in: Scientific reports, Vol. 6, pp. 33886, (2016) (PubMed).: "Cytochrome P450s and cholesterol homeostasis." in: Pharmacology & therapeutics, Vol. 112, Issue 3, pp. 761-73, (2006) (PubMed).
: "Differential expression of cholesterol hydroxylases in Alzheimer's disease." in: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34674-81, (2004) (PubMed).
: "Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain." in: Biochemistry, Vol. 42, Issue 48, pp. 14284-92, (2003) (PubMed).
Synonyms and alternative names related to CYP46A1
cytochrome P450 family 46 subfamily A member 1 (CYP46A1), cytochrome P450 family 46 subfamily A member 1 L homeolog (cyp46a1.L), cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 1 (cyp46a1.1), cytochrome P450, family 46 (cyp46a1), cytochrome P450 46A1 (PTRG_08343), cytochrome P450 46A1 (PTRG_09667), cytochrome P450, family 46, subfamily a, polypeptide 1 (Cyp46a1), cholesterol 24-hydroxylase (Sgly_1093), cytochrome P450, family 46, subfamily A, polypeptide 1 (CYP46A1), CP46, CYP46, Cyp46, CYP46A1, MGC147389, zgc:109896Protein level used designations for CYP46A1
- CH24H
- cholesterol 24-hydroxylase
- cytochrome P450 46A1
- cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
- cytochrome P450, family 46, subfamily A, polypeptide 1
- cytochrome P450, family 46
- cholestrol 24-hydroxylase
- cytochrome P450, 46 (cholesterol 24-hydroxylase)
- cytochrome P450, 46a1 (cholesterol 24-hydroxylase)
- cholesterol-24S-hydroxylase
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