ELAC2 antibody (AA 1-270)

Catalog No. ABIN6140108

This Rabbit Polyclonal antibody specifically detects ELAC2 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for ELAC2 antibody (AA 1-270) (ABIN6140108)

Target: ELAC2 (ElaC Homolog 2 (ELAC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELAC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ELAC2 Antibody

Binding Specificity: AA 1-270

Sequence: MWALCSLLRS AAGRTMSQGR TISQAPARRE RPRKDPLRHL RTREKRGPSG CSGGPNTVYL QVVAAGSRDS GAALYVFSEF NRYLFNCGEG VQRLMQEHKL KVARLDNIFL TRMHWSNVGG LSGMILTLKE TGLPKCVLSG PPQLEKYLEA IKIFSGPLKG IELAVRPHSA PEYEDETMTV YQIPIHSEQR RGKHQPWQSP ERPLSRLSPE RSSDSESNEN EPHLPHGVSQ RRGVRDSSLV VAFICKLHLK RGNFLVLKAK EMGLPVGTAA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ELAC2

Target: ELAC2 (ElaC Homolog 2 (ELAC2))

Alternative Name: ELAC2

Background: The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.,ELAC2,COXPD17,ELC2,HPC2,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,ELAC2

Molecular Weight: 50 kDa/56 kDa/87 kDa/92 kDa

Gene ID: 60528

UniProt: Q9BQ52