KNG1 antibody (AA 148-427)

Catalog No. ABIN6142985

This Rabbit Polyclonal antibody specifically detects KNG1 in WB. It exhibits reactivity toward Human.

Quick Overview for KNG1 antibody (AA 148-427) (ABIN6142985)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNG1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KNG1 Antibody

Binding Specificity: AA 148-427

Sequence: PISTQSPDLE PILRHGIQYF NNNTQHSSLF MLNEVKRAQR QVVAGLNFRI TYSIVQTNCS KENFLFLTPD CKSLWNGDTG ECTDNAYIDI QLRIASFSQN CDIYPGKDFV QPPTKICVGC PRDIPTNSPE LEETLTHTIT KLNAENNATF YFKIDNVKKA RVQVVAGKKY FIDFVARETT CSKESNEELT ESCETKKLGQ SLDCNAEVYV VPWEKKIYPT VNCQPLGMIS LMKRPPGFSP FRSSRIGEIK EETTSHLRSC EYKGRPPKAG AEPASEREVS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 148-427 of human Kininogen 1 (Kininogen 1 (KNG1)) (NP_000884.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: KNG1

Background: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.,KNG1,BDK,BK,KNG,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Cell Biology & Developmental Biology,Apoptosis,Cardiovascular,Blood,KNG1

Molecular Weight: 43 kDa/47 kDa/71 kDa

Gene ID: 3827

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process