MAN2B1 antibody (AA 640-850)

Catalog No. ABIN6143456

This Rabbit Polyclonal antibody specifically detects MAN2B1 in WB. It exhibits reactivity toward Human.

Quick Overview for MAN2B1 antibody (AA 640-850) (ABIN6143456)

Target: MAN2B1 (Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAN2B1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAN2B1 Antibody

Binding Specificity: AA 640-850

Sequence: TFFWYNASIG DNESDQASGA YIFRPNQQKP LPVSRWAQIH LVKTPLVQEV HQNFSAWCSQ VVRLYPGQRH LELEWSVGPI PVGDTWGKEV ISRFDTPLET KGRFYTDSNG REILERRRDY RPTWKLNQTE PVAGNYYPVN TRIYITDGNM QLTVLTDRSQ GGSSLRDGSL ELMVHRRLLK DDGRGVSEPL MENGSGAWVR GRHLVLLDTA Q

Cross-Reactivity: Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 640-850 of human MAN2B1 (NP_000519.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MAN2B1

Target: MAN2B1 (Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1))

Alternative Name: MAN2B1

Background: This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,MAN2B1,LAMAN,MANB,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,MAN2B1

Molecular Weight: 113 kDa

Gene ID: 4125

UniProt: O00754