TNNI1 antibody

Catalog No. ABIN614371

This Mouse Monoclonal antibody specifically detects TNNI1 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for TNNI1 antibody (ABIN614371)

Target: TNNI1 (Slow Skeletal Troponin I (TNNI1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNNI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 12F10

Product Details anti-TNNI1 Antibody

Specificity: Recognizes Troponin I Skeletal (TNNI). Less than 0.05 % cross-reactivity with Cardiac TNI

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Protein A Chromatography.

Immunogen: Mouse Skeletal muscle Troponin I.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4 with 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for TNNI1

Target: TNNI1 (Slow Skeletal Troponin I (TNNI1))

Background: Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium. This antibody reacts with subunit I of the troponin complex in human myocardium, where it is the only troponin I isotype present. It does not cross-react with troponin I of skeletal muscle cells.Synonyms: TNNI1

Gene ID: 7135

NCBI Accession: NP_003272

UniProt: P19237