MFN2 antibody (AA 687-757)

Catalog No. ABIN6143801

This Rabbit Polyclonal antibody specifically detects MFN2 in WB and IHC. It exhibits reactivity toward Mouse.

Quick Overview for MFN2 antibody (AA 687-757) (ABIN6143801)

Target: MFN2 (Mitofusin 2 (MFN2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MFN2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MFN2 Antibody

Binding Specificity: AA 687-757

Sequence: QVQQELSGTF AHLCQQVDIT RDNLEQEIAA MNKKVEALDS LQSRAKLLRN KAGWLDSELN MFTHQYLQPS R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 687-757 of mouse Mitofusin 2 (NP_573464.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MFN2

Target: MFN2 (Mitofusin 2 (MFN2))

Alternative Name: MFN2

Background: This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.,MFN2,CMT2A,CMT2A2,CMT2A2A,CMT2A2B,CPRP1,HMSN6A,HSG,MARF,mitofusin-2,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Autophagy,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Mitophagy fission and fusion,Neuroscience,Neurodegenerative Diseases,Mitochondrial Control of Autophagy,MFN2

Molecular Weight: 68 kDa/86 kDa

Gene ID: 170731

Pathways: Skeletal Muscle Fiber Development