SMCR7L antibody (AA 40-280)

Catalog No. ABIN6143839

The Rabbit Polyclonal anti-SMCR7L antibody has been validated for WB. It is suitable to detect SMCR7L in samples from Human.

Quick Overview for SMCR7L antibody (AA 40-280) (ABIN6143839)

Target: SMCR7L (Smith-Magenis Syndrome Chromosome Region, Candidate 7-Like (SMCR7L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMCR7L antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMCR7L Antibody

Binding Specificity: AA 40-280

Sequence: GIATLAVKRM YDRAISAPTS PTRLSHSGKR SWEEPNWMGS PRLLNRDMKT GLSRSLQTLP TDSSTFDTDT FCPPRPKPVA RKGQVDLKKS RLRMSLQEKL LTYYRNRAAI PAGEQARAKQ AAVDICAELR SFLRAKLPDM PLRDMYLSGS LYDDLQVVTA DHIQLIVPLV LEQNLWSCIP GEDTIMNVPG FFLVRRENPE YFPRGSSYWD RCVVGGYLSP KTVADTFEKV VAGSINWPAI G

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human MIEF1 (NP_061881.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SMCR7L

Target: SMCR7L (Smith-Magenis Syndrome Chromosome Region, Candidate 7-Like (SMCR7L))

Alternative Name: MIEF1

Background: Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.,MIEF1,HSU79252,MID51,SMCR7L,dJ1104E15.3,Cell Biology & Developmental Biology,MIEF1

Molecular Weight: 8 kDa/15 kDa/51 kDa

Gene ID: 54471

UniProt: Q9NQG6