MMP13 antibody (AA 262-471)

Catalog No. ABIN6143903

This anti-MMP13 antibody is a Rabbit Polyclonal antibody detecting MMP13 in WB and IF. Suitable for Human.

Quick Overview for MMP13 antibody (AA 262-471) (ABIN6143903)

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP13 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-MMP13 Antibody

Binding Specificity: AA 262-471

Sequence: IQSLYGPGDE DPNPKHPKTP DKCDPSLSLD AITSLRGETM IFKDRFFWRL HPQQVDAELF LTKSFWPELP NRIDAAYEHP SHDLIFIFRG RKFWALNGYD ILEGYPKKIS ELGLPKEVKK ISAAVHFEDT GKTLLFSGNQ VWRYDDTNHI MDKDYPRLIE EDFPGIGDKV DAVYEKNGYI YFFNGPIQFE YSIWSNRIVR VMPANSILWC

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 262-471 of human MMP13 (NP_002418.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MMP13

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Alternative Name: MMP13

Background: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11.,MMP13,CLG3,MANDP1,MDST,MMP-13,Cancer,Tumor biomarkers,Invasion and Metastasis,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,MMPs,Ubiquitin,Cardiovascular,Angiogenesis,MMP13

Molecular Weight: 53 kDa

Gene ID: 4322

UniProt: P45452