COX2 antibody (AA 100-200)

Catalog No. ABIN6144099

The Rabbit Polyclonal anti-COX2 antibody has been validated for WB and IHC. It is suitable to detect COX2 in samples from Mouse.

Quick Overview for COX2 antibody (AA 100-200) (ABIN6144099)

Target: COX2 (Cytochrome C Oxidase Subunit II (COX2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-COX2 Antibody

Binding Specificity: AA 100-200

Sequence: MGHQWYWSYE YTDYEDLCFD SYMIPTNDLK PGELRLLEVD NRVVLPMELP IRMLISSEDV LHSWAVPSLG LKTDAIPGRL NQATVTSNRP GLFYGQCSEI C

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of mouse MTCO2 (NP_904331.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for COX2

Target: COX2 (Cytochrome C Oxidase Subunit II (COX2))

Alternative Name: MT-CO2

Background: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII, ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII and cytochrome c oxidase (complex IV, CIV, that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS are transferred via the dinuclear copper A center (CU(A of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC formed by heme A3 and copper B (CU(B. The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.,MT-CO2,COII,MTCO2,COX2,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Cytochromes,Mitochondrial markers,Oxidative phosphorylation,Neuroscience,Neurodegenerative Diseases,MT-CO2

Molecular Weight: 25 kDa

Gene ID: 17709

UniProt: P00403

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation