MYH7 antibody (AA 1766-1935)

Catalog No. ABIN6144239

This Rabbit Polyclonal antibody specifically detects MYH7 in WB, IHC and IF. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for MYH7 antibody (AA 1766-1935) (ABIN6144239)

Target: MYH7 (Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYH7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MYH7 Antibody

Binding Specificity: AA 1766-1935

Sequence: AEELKKEQDT SAHLERMKKN MEQTIKDLQH RLDEAEQIAL KGGKKQLQKL EARVRELENE LEAEQKRNAE SVKGMRKSER RIKELTYQTE EDRKNLLRLQ DLVDKLQLKV KAYKRQAEEA EEQANTNLSK FRKVQHELDE AEERADIAES QVNKLRAKSR DIGTKGLNEE

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1766-1935 of human MYH7/beta-MHC (NP_000248.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-MYH7 antibody (ABIN6144239)

Kumar, Wang, Liu, Ding, Dong, Zheng, Ye, Liu: "Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α Mechanisms." in: Hypertension (Dallas, Tex. : 1979), Vol. 72, Issue 2, pp. 331-342, (2018) (PubMed).

Fan, Long, Yan, Wang, Shi, Bao, Hu, Li, Chen, Zheng, Yan: "Dietary leucine supplementation alters energy metabolism and induces slow-to-fast transitions in longissimus dorsi muscle of weanling piglets." in: The British journal of nutrition, Vol. 117, Issue 9, pp. 1222-1234, (2017) (PubMed).

Target Details for MYH7

Target: MYH7 (Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7))

Alternative Name: MYH7

Background: Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.,MYH7,CMD1S,CMH1,MPD1,MYHCB,SPMD,SPMM,myosin-7,MYH7,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Motor Proteins,MYH7

Molecular Weight: 223 kDa

Gene ID: 4625

UniProt: P12883