N4BP1 antibody (AA 190-590)

Catalog No. ABIN6144311

This anti-N4BP1 antibody is a Rabbit Polyclonal antibody detecting N4BP1 in WB and IF. Suitable for Mouse.

Quick Overview for N4BP1 antibody (AA 190-590) (ABIN6144311)

Target: N4BP1 (NEDD4 Binding Protein 1 (N4BP1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This N4BP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-N4BP1 Antibody

Binding Specificity: AA 190-590

Sequence: TQGEESLFET DDDVITVGDV RPPEYTQSAA TGPSSARDEV VVQEDSRNKA RTPVSELTKH MDTVFSSSPD VLFVPVNGLS PDEDALSKDR VCHKRRSSDT EERHTKKQFS LENVPEGELL PDGKGSAGNE VIDLSDPASN STNLSPDGKD TTEEMEYNIL VNFFKTMGYS QEIVEKVIRE YGPSTEPLLL LEEIEKENKR LQEDRDFPPC TVYPDASQSR NAGVGSTTNE LTADSTPKKA QSHTEQSMVE RFSQLPFKDS KHCTSNCKVN SFRTVPVGQK QEIWGSKQNS SCTVDLETDG HSASAASASP KDISFVSRGA SGHQQRNPAF PENGFQQQTE PLLPNNTKPA CEKRSGSCSS PQPKPNYPPL SPPLPLPQLL PSVTEARLGG SSDHIDSSVT G

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 190-590 of mouse N4BP1 (NP_085040.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for N4BP1

Target: N4BP1 (NEDD4 Binding Protein 1 (N4BP1))

Alternative Name: N4BP1

Background: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs, thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity. Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity. Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity.,N4BP1,Epigenetics & Nuclear Signaling,N4BP1

Molecular Weight: 99 kDa

Gene ID: 80750

UniProt: O75113