NPHP1 antibody (AA 345-614)

Catalog No. ABIN6144768

This Rabbit Polyclonal antibody specifically detects NPHP1 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for NPHP1 antibody (AA 345-614) (ABIN6144768)

Target: NPHP1 (Nephronophthisis 1 (Juvenile) (NPHP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPHP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-NPHP1 Antibody

Binding Specificity: AA 345-614

Sequence: PDLGILFELG ISYIRNSTGE RGELSCGWVF LKLFDASGVP IPAKTYELFL NGGTPYEKGI EVDPSISRRA HGSVFYQIMT MRRQPQLLVK LRSLNRRSRN VLSLLPETLI GNMCSIHLLI FYRQILGDVL LKDRMSLQST DLISHPMLAT FPMLLEQPDV MDALRSSWAG KESTLKRSEK RDKEFLKSTF LLVYHDCVLP LLHSTRLPPF RWAEEETETA RWKVITDFLK QNQENQGALQ ALLSPDGVHE PFDLSEQTYD FLGEMRKNAV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 345-614 of human NPHP1 (NP_001121651.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NPHP1

Target: NPHP1 (Nephronophthisis 1 (Juvenile) (NPHP1))

Alternative Name: NPHP1

Background: This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding different isoforms have been found for this gene.,NPHP1,JBTS4,NPH1,SLSN1,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,NPHP1

Molecular Weight: 69 kDa/77 kDa/83 kDa

Gene ID: 4867

UniProt: O15259