Vitamin D Receptor antibody (AA 1-428)

Catalog No. ABIN614675

The Mouse Monoclonal anti-Vitamin D Receptor antibody is suitable to detect Vitamin D Receptor in samples from Human. It has been validated for IHC (p) and EIA.

Quick Overview for Vitamin D Receptor antibody (AA 1-428) (ABIN614675)

Target: Vitamin D Receptor (VDR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Vitamin D Receptor antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: 2F4

Product Details anti-Vitamin D Receptor Antibody

Binding Specificity: AA 1-428

Specificity: This antibody reacts to Vitamin D Receptor (VDR).

Purification: Protein A Chromatography

Immunogen: Recombinant protein, VDR (AAH60832, 1 a.a. ~ 428 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Genename: VDR

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for Vitamin D Receptor

Target: Vitamin D Receptor (VDR)

Alternative Name: Vitamin D3 Receptor / NR1I1

Target Type: Chemical

Background: The vitamin D receptor, a NR1 Thyroid Hormone-Like Receptor, is activated by calcitriol, the active hormonal form of vitamin D. The activated receptor binds DNA at a specific vitamin D-responsive element and promotes transcription of vitamin D target genes such as osteocalcin, the most abundant noncollagenous protein in bone. The vitamin D receptor affects growth, bone formation, and female reproduction. For example, this receptor modulates the growth and differentiation of keratinocytes and mediates the beneficial effects of vitamin D on psoriatic skin. It also inhibits hormone secretion by and proliferation of parathyroid cells. The vitamin D receptor functions either as a homodimer or as a heterodimer of vitamin D and retinoid acid X receptor subunits. Inactivation of the receptor leads to hypocalcemia and Rickets-alopecia syndrome. Recently, the vitamin D receptor has been shown to function as a receptor for the secondary bile acid lithocholic acid (LCA), which is hepatotoxic and a potential enteric carcinogen. Activation of VDR by LCA or vitamin D induced expression in vivo of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestine. An alternatively spliced vitamin D receptor that has an altered ligand-binding domain has been isolated from rats.Synonyms: 1, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR

Gene ID: 7421

NCBI Accession: NP_000367

UniProt: P11473

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway