SAV1 antibody (AA 1-210)

Catalog No. ABIN6147400

The Rabbit Polyclonal anti-SAV1 antibody has been validated for WB. It is suitable to detect SAV1 in samples from Human.

Quick Overview for SAV1 antibody (AA 1-210) (ABIN6147400)

Target: SAV1 (Salvador Homolog 1 (SAV1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAV1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SAV1 Antibody

Binding Specificity: AA 1-210

Sequence: MLSRKKTKNE VSKPAEVQGK YVKKETSPLL RNLMPSFIRH GPTIPRRTDI CLPDSSPNAF STSGDVVSRN QSFLRTPIQR TPHEIMRRES NRLSAPSYLA RSLADVPREY GSSQSFVTEV SFAVENGDSG SRYYYSDNFF DGQRKRPLGD RAHEDYRYYE YNHDLFQRMP QNQGRHASGI GRVAATSLGN LTNHGSEDLP LPPGWSVDWT

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SAV1 (NP_068590.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:4000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SAV1

Target: SAV1 (Salvador Homolog 1 (SAV1))

Alternative Name: SAV1

Background: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.,SAV1,SAV,WW45,WWP4,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Hippo Signaling Pathway,SAV1

Molecular Weight: 44 kDa

Gene ID: 60485

UniProt: Q9H4B6

Pathways: Stem Cell Maintenance