Septin 2 antibody (AA 112-361)

Catalog No. ABIN6147552

The Rabbit Polyclonal anti-Septin 2 antibody has been validated for WB and IF. It is suitable to detect Septin 2 in samples from Human.

Quick Overview for Septin 2 antibody (AA 112-361) (ABIN6147552)

Target: Septin 2 (SEPT2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Septin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Septin 2 Antibody

Binding Specificity: AA 112-361

Sequence: RDCFKTIISY IDEQFERYLH DESGLNRRHI IDNRVHCCFY FISPFGHGLK PLDVAFMKAI HNKVNIVPVI AKADTLTLKE RERLKKRILD EIEEHNIKIY HLPDAESDED EDFKEQTRLL KASIPFSVVG SNQLIEAKGK KVRGRLYPWG VVEVENPEHN DFLKLRTMLI THMQDLQEVT QDLHYENFRS ERLKRGGRKV ENEDMNKDQI LLEKEAELRR MQEMIARMQA QMQMQMQGGD GDGGALGHHV

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 112-361 of human Septin 2 (NP_004395.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Septin 2

Target: Septin 2 (SEPT2)

Alternative Name: 2-Sep

Background: Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.,SEPT2,DIFF6,NEDD-5,NEDD5,Pnutl3,hNedd5,septin-2,Cell Biology & Developmental Biology,Cell Cycle,Immunology & Inflammation,Cytokines,2-Sep

Molecular Weight: 41 kDa/42 kDa/45 kDa

Gene ID: 4735

UniProt: Q15019