SETMAR antibody (AA 20-300)

Catalog No. ABIN6147659

The Rabbit Polyclonal anti-SETMAR antibody has been validated for IHC. It is suitable to detect SETMAR in samples from Human.

Quick Overview for SETMAR antibody (AA 20-300) (ABIN6147659)

Target: SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETMAR antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-SETMAR Antibody

Binding Specificity: AA 20-300

Sequence: KPEAPTEQLD VACGQENLPV GAWPPGAAPA PFQYTPDHVV GPGADIDPTQ ITFPGCICVK TPCLPGTCSC LRHGENYDDN SCLRDIGSGG KYAEPVFECN VLCRCSDHCR NRVVQKGLQF HFQVFKTHKK GWGLRTLEFI PKGRFVCEYA GEVLGFSEVQ RRIHLQTKSD SNYIIAIREH VYNGQVMETF VDPTYIGNIG RFLNHSCEPN LLMIPVRIDS MVPKLALFAA KDIVPEEELS YDYSGRYLNL TVSEDKERLD HGKLRKPCYC GAKSCTAFLP F

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human SETMAR (NP_006506.3).

Isotype: IgG

Application Details

Application Notes: IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SETMAR

Target: SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))

Alternative Name: SETMAR

Background: This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants.,SETMAR,METNASE,Mar1,Epigenetics & Nuclear Signaling,SETMAR

Molecular Weight: 40 kDa/62 kDa/78 kDa

Gene ID: 6419

UniProt: Q53H47

Pathways: Positive Regulation of Response to DNA Damage Stimulus