SUPV3L1 antibody (AA 577-786)

Catalog No. ABIN6148741

This Rabbit Polyclonal antibody specifically detects SUPV3L1 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for SUPV3L1 antibody (AA 577-786) (ABIN6148741)

Target: SUPV3L1 (Suppressor of Var1, 3-Like 1 (SUPV3L1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUPV3L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SUPV3L1 Antibody

Binding Specificity: AA 577-786

Sequence: APINKKQPFV CSSLLQFARQ YSRNEPLTFA WLRRYIKWPL LPPKNIKDLM DLEAVHDVLD LYLWLSYRFM DMFPDASLIR DLQKELDGII QDGVHNITKL IKMSETHKLL NLEGFPSGSQ SRLSGTLKSQ ARRTRGTKAL GSKATEPPSP DAGELSLASR LVQQGLLTPD MLKQLEKEWM TQQTEHNKEK TESGTHPKGT RRKKKEPDSD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 577-786 of human SUPV3L1 (NP_003162.2).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:4000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SUPV3L1

Target: SUPV3L1 (Suppressor of Var1, 3-Like 1 (SUPV3L1))

Alternative Name: SUPV3L1

Background: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria, regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.,SUPV3L1,SUV3,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Mitochondrial metabolism,SUPV3L1

Molecular Weight: 87 kDa

Gene ID: 6832

UniProt: Q8IYB8