TBC1D23 antibody (AA 250-600)

Catalog No. ABIN6148882

The Rabbit Polyclonal anti-TBC1D23 antibody has been validated for WB. It is suitable to detect TBC1D23 in samples from Human.

Quick Overview for TBC1D23 antibody (AA 250-600) (ABIN6148882)

Target: TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D23 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TBC1D23 Antibody

Binding Specificity: AA 250-600

Sequence: SDSKEEVIKF LENTPSSLNI EDIEDLFSLA QYYCSKTPAS FRKDNHHLFG STLLGIKDDD ADLSQALCLA ISVSEILQAN QLQGEGVRFF VVDCRPAEQY NAGHLSTAFH LDSDLMLQNP SEFAQSVKSL LEAQKQSIES GSIAGGEHLC FMGSGREEED MYMNMVLAHF LQKNKEYVSI ASGGFMALQQ HLADINVDGP ENGYGHWIAS TSGSRSSINS VDGESPNGSS DRGMKSLVNK MTVALKTKSV NVREKVISFI ENTSTPVDRM SFNLPWPDRS CTERHVSSSD RVGKPYRGVK PVFSIGDEEE YDTDEIDSSS MSDDDRKEVV NIQTWINKPD VKHHFPCKEV K

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-600 of human TBC1D23 (NP_001186127.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TBC1D23

Target: TBC1D23 (TBC1 Domain Family, Member 23 (TBC1D23))

Alternative Name: TBC1D23

Background: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. Plays a role in brain development, including in cortical neuron positioning (By similarity. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS challenge (By similarity.,TBC1D23,NS4ATP1,TBC1D23

Molecular Weight: 76 kDa/78 kDa

Gene ID: 55773

UniProt: Q9NUY8