UMPS antibody (AA 100-260)

Catalog No. ABIN6149927

This Rabbit Polyclonal antibody specifically detects UMPS in WB and IF. It exhibits reactivity toward Human.

Quick Overview for UMPS antibody (AA 100-260) (ABIN6149927)

Target: UMPS (Uridine Monophosphate Synthetase (UMPS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UMPS antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-UMPS Antibody

Binding Specificity: AA 100-260

Sequence: TKDYGTKRLV EGTINPGETC LIIEDVVTSG SSVLETVEVL QKEGLKVTDA IVLLDREQGG KDKLQAHGIR LHSVCTLSKM LEILEQQKKV DAETVGRVKR FIQENVFVAA NHNGSPLSIK EAPKELSFGA RAELPRIHPV ASKLLRLMQK KETNLCLSAD V

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-260 of human UMPS (NP_000364.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UMPS

Target: UMPS (Uridine Monophosphate Synthetase (UMPS))

Alternative Name: UMPS

Background: This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.,UMPS,OPRT,Epigenetics & Nuclear Signaling,Endocrine & Metabolism,Nucleotide metabolism,Purine and pyrimidine synthesis,UMPS

Molecular Weight: 22 kDa/33 kDa/42 kDa/52 kDa

Gene ID: 7372

UniProt: P11172

Pathways: Ribonucleoside Biosynthetic Process