ZRANB3 antibody (AA 818-1077)

Catalog No. ABIN6150540

This anti-ZRANB3 antibody is a Rabbit Polyclonal antibody detecting ZRANB3 in WB. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for ZRANB3 antibody (AA 818-1077) (ABIN6150540)

Target: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZRANB3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ZRANB3 Antibody

Binding Specificity: AA 818-1077

Sequence: ITKQQTKQNC TKRYITKEDV AVASMDKVKN VGGHVRLITK ESRPRDPFTK KLLEDGACVP FLNPYTVQAD LTVKPSTSKG YLQAVDNEGN PLCLRCQQPT CQTKQACKAN SWDSRFCSLK CQEEFWIRSN NSYLRAKVFE TEHGVCQLCN VNAQELFLRL RDAPKSQRKN LLYATWTSKL PLEQLNEMIR NPGEGHFWQV DHIKPVYGGG GQCSLDNLQT LCTVCHKERT ARQAKERSQV RRQSLASKHG SDITRFLVKK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 818-1077 of human ZRANB3 (NP_001273497.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:3000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-ZRANB3 antibody (ABIN6150540)

Margalef, Kotsantis, Borel, Bellelli, Panier, Boulton: "Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe." in: Cell, Vol. 172, Issue 3, pp. 439-453.e14, (2019) (PubMed).

Target Details for ZRANB3

Target: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Alternative Name: ZRANB3

Background: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.,ZRANB3,4933425L19Rik,AH2,Epigenetics & Nuclear Signaling,ZRANB3

Molecular Weight: 42 kDa/49 kDa/67 kDa/123 kDa

Gene ID: 84083

UniProt: Q5FWF4