DPPA3 antibody (C-Term)

Catalog No. ABIN6242290

This anti-DPPA3 antibody is a Rabbit Polyclonal antibody detecting DPPA3 in WB. Suitable for Human.

Quick Overview for DPPA3 antibody (C-Term) (ABIN6242290)

Target: DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPPA3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB50716

Product Details anti-DPPA3 Antibody

Binding Specificity: AA 145-179, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DPPA3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 145-179 amino acids from the C-terminal region of human DPPA3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for DPPA3

Target: DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))

Alternative Name: DPPA3

Background: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).

Molecular Weight: 17851

UniProt: Q6W0C5