JARID2 antibody (C-Term)

Catalog No. ABIN6242857

This anti-JARID2 antibody is a Rabbit Polyclonal antibody detecting JARID2 in WB. Suitable for Mouse.

Quick Overview for JARID2 antibody (C-Term) (ABIN6242857)

Target: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JARID2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB52505

Product Details anti-JARID2 Antibody

Binding Specificity: AA 1107-1141, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Jarid2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1107-1141 amino acids from the C-terminal region of Mouse Jarid2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for JARID2

Target: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Alternative Name: Jarid2

Background: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

Molecular Weight: 137445

UniProt: Q62315

Pathways: Chromatin Binding