FER antibody

Catalog No. ABIN6243361

This anti-FER antibody is a Mouse Monoclonal antibody detecting FER in WB, IF and FACS. Suitable for Mouse.

Quick Overview for FER antibody (ABIN6243361)

Target: FER (FER Tyrosine Kinase (FER))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This FER antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 1487CT794-8-50

Product Details anti-FER Antibody

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This Fer antibody is generated from a mouse immunized with a recombinant protein.

Isotype: IgG2a kappa

Application Details

Application Notes: IF: 1:25. WB: 1:4000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for FER

Target: FER (FER Tyrosine Kinase (FER))

Alternative Name: Fer

Background: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3 according to PubMed:< a href="http://www.uniprot.org/citations/10878010" target="_blank">10878010 and PubMed:< a href="http://www.uniprot.org/citations/19159681" target="_blank">19159681, but clearly plays a redundant role in STAT3 phosphorylation. According to PubMed:< a href="http://www.uniprot.org/citations/11134346" target="_blank">11134346, cells where wild type FER has been replaced by a kinase-dead mutant show no reduction in STAT3 phosphorylation. Phosphorylates TMF1. Isoform 3 lacks kinase activity.

Molecular Weight: 94579

UniProt: P70451