HSP70 1A antibody

Catalog No. ABIN6243695

This Rabbit Polyclonal antibody specifically detects HSP70 1A in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for HSP70 1A antibody (ABIN6243695)

Target: HSP70 1A (HSPA1A) (Heat Shock 70kDa Protein 1A (HSPA1A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSP70 1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB58828

Product Details anti-HSP70 1A Antibody

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HSPA1A/HSPA1B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human HSPA1A/HSPA1B.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for HSP70 1A

Target: HSP70 1A (HSPA1A) (Heat Shock 70kDa Protein 1A (HSPA1A))

Alternative Name: HSPA1A/HSPA1B

Background: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.

UniProt: P0DMV8, P0DMV9

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process