UBASH3A antibody (Internal Region)

Catalog No. ABIN6257504

This Rabbit Polyclonal antibody specifically detects UBASH3A in ELISA, WB, IF and ICC. It exhibits reactivity toward Human.

Quick Overview for UBASH3A antibody (Internal Region) (ABIN6257504)

Target: UBASH3A (Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBASH3A antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-UBASH3A Antibody

Binding Specificity: Internal Region

Specificity: UBASH3A Antibody detects endogenous levels of total UBASH3A.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human UBASH3A, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for UBASH3A

Target: UBASH3A (Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A))

Alternative Name: UBASH3A

Background:

Description: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral  pH . May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Gene: UBASH3A

Molecular Weight: 74 kDa

Gene ID: 53347

UniProt: P57075