TOPORS antibody (C-Term)

Catalog No. ABIN6259220

This Rabbit Polyclonal antibody specifically detects TOPORS in WB, ELISA and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for TOPORS antibody (C-Term) (ABIN6259220)

Target: TOPORS (Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOPORS antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TOPORS Antibody

Binding Specificity: C-Term

Specificity: TOPRS Antibody detects endogenous levels of total TOPRS.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TOPRS, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for TOPORS

Target: TOPORS (Topoisomerase I Binding, arginine/serine-Rich, E3 Ubiquitin Protein Ligase (TOPORS))

Alternative Name: TOPORS

Background:

Description: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.

Gene: TOPORS

Gene ID: 10210

UniProt: Q9NS56

Pathways: Maintenance of Protein Location