ATXN7L3 antibody (Ataxin 7-Like 3) Primary Antibody
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- Target
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Clonality
- Polyclonal
- Conjugate
- This ATXN7L3 antibody is un-conjugated
- Application
- ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
- Specificity
- ATXN7L3 Antibody detects endogenous levels of total ATXN7L3
- Cross-Reactivity
- Human, Mouse (Murine)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human ATXN7L3
- Isotype
- IgG
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- Application Notes
- WB 1:1000-3000 IHC 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
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- Target
- Alternative Name
- ATXN7L3 (ATXN7L3 Antibody Abstract)
- Background
Description: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583).
Gene: ATXN7L3
- Molecular Weight
- 39 kDa
- Gene ID
- 56970
- UniProt
- Q14CW9