ATXN7L3 antibody (Middle Region)

Catalog No. ABIN2790607

Product Details anti-ATXN7L3 Antibody

Target: ATXN7L3 (Ataxin 7-Like 3 (ATXN7L3))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATXN7L3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MNKSESDQED NDDINDNDWS YGSEKKAKKR KSDKLWYLPF QNPNSPRRSK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against ATXN7L3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human ATXN7L3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 354 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATXN7L3

Target: ATXN7L3 (Ataxin 7-Like 3 (ATXN7L3))

Alternative Name: ATXN7L3 (ATXN7L3 Products)

Synonyms: E030022H21Rik antibody, si:busm1-180g5.4 antibody, si:dz180g5.4 antibody, wu:fj12f07 antibody, zgc:136438 antibody, zgc:158566 antibody, ataxin 7 like 3 antibody, ataxin 7-like 3 antibody, ATXN7L3 antibody, Atxn7l3 antibody, atxn7l3 antibody

Background: ATXN7L3 is a component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, ATXN7L3 participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.
Alias Symbols: DKFZp761G2113
Protein Interaction Partner: SIRT1, USP22, SECISBP2, SERTAD1, PICK1, USP6, UCHL3, HIST2H2BE, HIST2H2AC, ATXN7, KAT2A, ENY2, TAF5L, SUPT3H, TRRAP, TAF10,
Protein Size: 354

Molecular Weight: 38 kDa

Gene ID: 56970

NCBI Accession: NM_020218, NP_064603

UniProt: Q14CW9