GJA1 antibody (Gap Junction Protein, alpha 1, 43kDa) Primary Antibody
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- Target
- GJA1
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Clonality
- Polyclonal
- Conjugate
- This GJA1 antibody is un-conjugated
- Application
- ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
- Specificity
- Connexin 43 antibody detects endogenous levels of total Connexin 43
- Cross-Reactivity
- Human, Mouse (Murine), Rat (Rattus)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human Connexin 43
- Isotype
- IgG
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- Application Notes
- WB: 1:500~1:3000 IHC: 1:50~1:200 IF/ICC: 1:100~1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
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Zhao, Wu, Chen, Ji, Zheng: "TGF-β1 and connexin-43 expression in neurogenic bladder from rats with sacral spinal cord injury." in: Neurourology and urodynamics, 2018 (PubMed).
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Zhao, Wu, Chen, Ji, Zheng: "TGF-β1 and connexin-43 expression in neurogenic bladder from rats with sacral spinal cord injury." in: Neurourology and urodynamics, 2018 (PubMed).
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- Target
- GJA1
- Alternative Name
- Connexin 43 (GJA1 Antibody Abstract)
- Synonyms
- AVSD3, CX43, DFNB38, GJAL, HLHS1, HSS, ODDD, Cx43, AU042049, AW546267, Cnx43, Cx43alpha1, Gja-1, Npm1, connexin43, cx43a1, gja1, zfCx43.3, connexin 43, gja1-A, cx43, gjal, oddd, dfnb38, gap junction protein alpha 1, gap junction protein, alpha 1, connexin 43, gap junction protein alpha 1 L homeolog, CONNEXIN 43 protein, GJA1, Gja1, cx43, gja1.L, gja1, CONNEXIN 43
- Background
Description: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).
Gene: GJA1
- Molecular Weight
- 43kDa
- Gene ID
- 2697
- UniProt
- P17302
- Pathways
- MAPK Signaling, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization