HORMAD1 antibody (C-Term)

Catalog No. ABIN6262338

The Rabbit Polyclonal anti-HORMAD1 antibody has been validated for ELISA, WB, ICC and IF. It is suitable to detect HORMAD1 in samples from Human and Mouse.

Quick Overview for HORMAD1 antibody (C-Term) (ABIN6262338)

Target: HORMAD1 (HORMA Domain Containing 1 (HORMAD1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HORMAD1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-HORMAD1 Antibody

Binding Specificity: C-Term

Specificity: HORMAD1 Antibody detects endogenous levels of total HORMAD1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HORMAD1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for HORMAD1

Target: HORMAD1 (HORMA Domain Containing 1 (HORMAD1))

Alternative Name: HORMAD1

Background:

Description: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.

Gene: HORMAD1

Molecular Weight: 45kDa

Gene ID: 84072

UniProt: Q86X24

Pathways: M Phase