IL28A antibody (N-Term)

Catalog No. ABIN6262560

The Rabbit Polyclonal anti-IL28A antibody has been validated for WB, ELISA, ICC and IF. It is suitable to detect IL28A in samples from Human.

Quick Overview for IL28A antibody (N-Term) (ABIN6262560)

Target: IL28A (Interleukin 28A (Interferon, lambda 2) (IL28A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL28A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-IL28A Antibody

Binding Specificity: N-Term

Specificity: IL28A Antibody detects endogenous levels of total IL28A.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human IL28A, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for IL28A

Target: IL28A (Interleukin 28A (Interferon, lambda 2) (IL28A))

Alternative Name: IFNL2

Background:

Description: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Gene: IFNL2

Molecular Weight: 22 kDa

Gene ID: 282616

UniProt: Q8IZJ0