NEIL2 antibody (Nei Endonuclease VIII-Like 2 (E. Coli))

Details for Product anti-NEIL2 Antibody No. ABIN6263588
Antigen
Reactivity
Human, Mouse (Murine)
45
12
9
5
4
2
2
2
1
1
Host
Rabbit
37
8
Clonality
Polyclonal
Conjugate
This NEIL2 antibody is un-conjugated
3
2
2
2
2
2
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
40
18
3
2
1
1
1
1
Options
Immunogen A synthesized peptide derived from human NEIL2
Isotype IgG
Specificity NEIL2 Antibody detects endogenous levels of total NEIL2
Cross-Reactivity Human, Mouse (Murine)
Purification The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Antigen
Alternative Name NEIL2 (NEIL2 Antibody Abstract)
Background

Description: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

Gene: NEIL2

Molecular Weight 37 kDa
Gene ID 252969
UniProt Q969S2
Pathways DNA Damage Repair
Application Notes WB 1:1000-3000 IHC 1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-Nei Endonuclease VIII-Like 2 (E. Coli) (NEIL2) antibody (ABIN6263588) Western blot analysis NEIL2 using HuvEc whole cell lysates
Image no. 2 for anti-Nei Endonuclease VIII-Like 2 (E. Coli) (NEIL2) antibody (ABIN6263588) Western blot analysis of extracts from HepG2, using NEIL2 Antibody.
Image no. 3 for anti-Nei Endonuclease VIII-Like 2 (E. Coli) (NEIL2) antibody (ABIN6263588) ABIN6279411 at 1/100 staining Mouse pancreas tissue by IHC-P. The sample was formalde...