NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1)

Details for Product anti-NOD1 Antibody No. ABIN6263678
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
103
48
30
Host
Rabbit
107
7
5
Clonality
Polyclonal
Conjugate
This NOD1 antibody is un-conjugated
6
5
5
5
5
5
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
108
57
27
18
7
6
5
4
3
3
2
1
Options
Immunogen A synthesized peptide derived from human NOD1
Isotype IgG
Specificity NOD1 Antibody detects endogenous levels of total NOD1
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Antigen
Alternative Name NOD1 (NOD1 Antibody Abstract)
Background

Description: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.

Gene: NOD1

Molecular Weight 108kDa
Gene ID 10392
UniProt Q9Y239
Pathways Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
Application Notes WB 1:500-1:2000 IHC 1:50-1:200
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1) antibody (ABIN6263678) ABIN6276645 at 1/100 staining Human lung tissue by IHC-P. The sample was formaldehyde...
Image no. 2 for anti-Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1) antibody (ABIN6263678) Western blot analysis of Mouse bladder lysate using NOD1 antibody. The lane on the le...
Image no. 3 for anti-Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1) antibody (ABIN6263678) Western blot analysis of NOD1 expression in Rat brain lysate