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CD31 antibody (C-Term)

This Rabbit Polyclonal antibody specifically detects CD31 in WB, IHC, IF, ELISA and ICC. It exhibits reactivity toward Human and Mouse.
Catalog No. ABIN6264128

Quick Overview for CD31 antibody (C-Term) (ABIN6264128)

Target

See all CD31 (PECAM1) Antibodies
CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Reactivity

  • 383
  • 140
  • 79
  • 67
  • 43
  • 36
  • 21
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  • 11
  • 7
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  • 1
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Human, Mouse

Host

  • 249
  • 175
  • 42
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  • 3
  • 2
Rabbit

Clonality

  • 331
  • 145
  • 8
  • 1
Polyclonal

Conjugate

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  • 2
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  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
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This CD31 antibody is un-conjugated

Application

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  • 3
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  • 1
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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)
  • Binding Specificity

    • 68
    • 20
    • 16
    • 16
    • 14
    • 12
    • 7
    • 7
    • 7
    • 7
    • 4
    • 4
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    • 1
    • 1
    • 1
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    • 1
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    C-Term

    Specificity

    CD31 Antibody detects endogenous levels of total CD31.

    Predicted Reactivity

    Zebrafish

    Purification

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human CD31, corresponding to a region within C-terminal amino acids.

    Isotype

    IgG
  • Application Notes

    WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20 °C. Stable for 12 months from date of receipt.

    Expiry Date

    12 months
  • Target

    CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

    Alternative Name

    PECAM1

    Background

    Description: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells, PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity).

    Gene: PECAM1

    Molecular Weight

    82kDa

    Gene ID

    5175

    UniProt

    P16284

    Pathways

    Regulation of Actin Filament Polymerization
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