RASGRP2 antibody

Catalog No. ABIN6293518

This Rabbit Polyclonal antibody specifically detects RASGRP2 in WB. It exhibits reactivity toward Human.

Quick Overview for RASGRP2 antibody (ABIN6293518)

Target: RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASGRP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RASGRP2 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human RASGRP2

Isotype: IgG

Application Details

Application Notes: WB 1:200 - 1:2000

Comment:

Detected in platelets, neutrophils and T lymphocytes (at protein level), Expressed in brain where it is enriched in the striatum, Also expressed in the hematopoietic system, Detected in heart, brain, lung, placenta, liver, skeletal muscle and kidney

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for RASGRP2

Target: RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))

Alternative Name: RASGRP2

Background: The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene.

Molecular Weight: 69.248 kDa

Gene ID: 10235

UniProt: Q7LDG7

Pathways: TCR Signaling