CD79a antibody (AA 202-216)

Catalog No. ABIN6294396

This anti-CD79a antibody is a Rabbit Polyclonal antibody detecting CD79a in IHC. Suitable for Human, Mouse, Rat, Cow, Pig and Monkey.

Quick Overview for CD79a antibody (AA 202-216) (ABIN6294396)

Target: CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))

Reactivity: Human, Mouse, Rat, Cow, Pig, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD79a antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-CD79a Antibody

Binding Specificity: AA 202-216

Purpose: Rabbit anti-Human/Mouse/Rat/Monkey/Pig/Cow Recombinant CD79a Antibody [IHC only]

Specificity: Cell surface, cytoplasmic

Purification: Amino acids 202-216 (GTYQDVGSLNIADVQ) were used as the immunogen for the recombinant CD79a antibody.

Immunogen: Amino acids 202-216 (GTYQDVGSLNIADVQ) were used as the immunogen for the recombinant CD79a antibody.

Application Details

Application Notes: Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for CD79a

Target: CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))

Alternative Name: B-cell antigen receptor complex-associated protein alpha chain

Background:

Target Description: A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.

Gene Symbol: CD79A///IGA///MB1

Gene ID: 973

UniProt: P11912

Pathways: BCR Signaling