TEAD2 antibody (Center)

Catalog No. ABIN6294438

This anti-TEAD2 antibody is a Rabbit Polyclonal antibody detecting TEAD2 in . Suitable for Human and Mouse.

Quick Overview for TEAD2 antibody (Center) (ABIN6294438)

Target: TEAD2 (TEA Domain Family Member 2 (TEAD2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEAD2 antibody is un-conjugated

Application: Please inquire

Product Details anti-TEAD2 Antibody

Binding Specificity: AA 267-295, Center

Purpose: Rabbit Anti-TEAD2 (Center) Antibody

Immunogen: This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-295 amino acids from the Central region of human TEAD2.

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for TEAD2

Target: TEAD2 (TEA Domain Family Member 2 (TEAD2))

Alternative Name: TEAD2

Background:

Target Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Gene Symbol: TEAD2

Gene ID: 8463

UniProt: Q15562

Pathways: Regulation of Lipid Metabolism by PPARalpha, Tube Formation