Involucrin antibody (AA 421-568)

Catalog No. ABIN6294531

This anti-Involucrin antibody is a Mouse Monoclonal antibody detecting Involucrin in IHC, IF and FACS. Suitable for Human, Dog, Pig, Gorilla and Owl Monkey.

Quick Overview for Involucrin antibody (AA 421-568) (ABIN6294531)

Target: Involucrin (IVL)

Reactivity: Human, Dog, Pig, Gorilla, Owl Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This Involucrin antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-Involucrin Antibody

Binding Specificity: AA 421-568

Purpose: Mouse anti-Human/Gorilla/Owl Monkey/Pig/Dog Involucrin Antibody [Sodium Azide Free]

Specificity: Cytoplasmic

Purification: Purified involucrin from human keratinocytes was used as the immunogen for this Involucrin antibody. Its epitope maps between amino acids 421-568 of human involucrin.

Immunogen: Purified involucrin from human keratinocytes was used as the immunogen for this Involucrin antibody. Its epitope maps between amino acids 421-568 of human involucrin.

Application Details

Application Notes: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.1-0.2 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for Involucrin

Target: Involucrin (IVL)

Alternative Name: Involucrin

Background:

Target Description: Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal, expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.

Gene Symbol: IVL

Gene ID: 3713

UniProt: P07476