TIMP2 antibody (N-Term)

Catalog No. ABIN6295483

This Mouse Monoclonal antibody specifically detects TIMP2 in WB, IF and IHC (fp). It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for TIMP2 antibody (N-Term) (ABIN6295483)

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIMP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-TIMP2 Antibody

Binding Specificity: N-Term

Purpose: Mouse anti-Human/Mouse/Rat TIMP2 Antibody [Sodium Azide Free]

Specificity: Cytoplasmic, cell surface, secreted

Purification: An amino acid sequence from the N-terminal region of the human protein was used as the immunogen for this TIMP2 antibody.

Immunogen: An amino acid sequence from the N-terminal region of the human protein was used as the immunogen for this TIMP2 antibody.

Application Details

Application Notes: IHC (FFPE): 0.5-1 μg/mL for 30 min at RT
WB: 0.5-1 μg/mL
IF: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for TIMP2

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Alternative Name: Metalloproteinase inhibitor 2

Background:

Target Description: It recognizes a protein of 21 kDa, identified as tissue inhibitor of metalloproteinases 2 (TIMP2). It is closely related to TIMP1 and shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP9 or gelatinase B). TIMP2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Gene Symbol: TIMP2

Gene ID: 7077

UniProt: P16035

Pathways: cAMP Metabolic Process