FSHR antibody

Catalog No. ABIN6296013

This anti-FSHR antibody is a Mouse Monoclonal antibody detecting FSHR in IHC, IF and FACS. Suitable for Human.

Quick Overview for FSHR antibody (ABIN6296013)

Target: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FSHR antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-FSHR Antibody

Purpose: Mouse anti-Human FSH Receptor Antibody [Sodium Azide Free]

Specificity: Cytoplasmic, cell surface

Purification: A human recombinant protein was used as the immunogen for this FSHR antibody.

Immunogen: A human recombinant protein was used as the immunogen for this FSHR antibody.

Application Details

Application Notes: FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL for 30 min at RT

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for FSHR

Target: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Alternative Name: Follicle-stimulating hormone receptor

Background:

Target Description: Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome, a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.

Gene Symbol: FSHR///LGR1

Gene ID: 2492

UniProt: P23945

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Platelet-derived growth Factor Receptor Signaling