Histone H1 antibody

Catalog No. ABIN6297055

This Mouse Monoclonal antibody specifically detects Histone H1 in IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Histone H1 antibody (ABIN6297055)

Target: Histone H1 (H1F0) (H1 Histone Family, Member 0 (H1F0))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Histone H1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Histone H1 Antibody

Purpose: Mouse anti-Human/Mouse/Rat Histone H1 Antibody [IHC only]

Specificity: Nuclear

Purification: Recombinant full-length human protein was used as the immunogen for the Histone H1 antibody.

Immunogen: Recombinant full-length human protein was used as the immunogen for the Histone H1 antibody.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for Histone H1

Target: Histone H1 (H1F0) (H1 Histone Family, Member 0 (H1F0))

Alternative Name: Histone H1.0

Background:

Target Description: Eukaryotic histones are basic and water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer, formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80 % of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.

Gene Symbol: H1F0///H1FV

Gene ID: 3005

UniProt: P07305