Thymidylate Synthetase (TYMS) antibody

Details for Product No. ABIN6297576
Antigen
  • FN1
  • ECK2823
  • JW2795
  • ts
  • Ts
  • HST422
  • TMS
  • TS
  • thymidylate synthetase
  • contains intron in T4 phage
  • ThyE
  • thymidylate synthase
  • thymidylate synthetase L homeolog
  • TYMS
  • thyA
  • td
  • thyE
  • DDA3937_RS04960
  • tyms.L
  • XBJ1_RS15770
  • EAMY_RS20680
  • Tyms
Reactivity
Human
277
32
28
3
2
2
2
2
1
1
1
Host
Mouse
197
69
11
Clonality
Monoclonal
Conjugate
Un-conjugated
10
7
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC)
148
147
121
92
73
67
63
51
49
14
10
9
7
6
5
3
2
1
Options
Purpose Mouse anti-Human Thymidylate Synthase Antibody [IHC only]
Immunogen Recombinant human Thymidylate synthase was used as the immunogen for this antibody.
Specificity Cytoplasmic
Purification Recombinant human Thymidylate synthase was used as the immunogen for this antibody.
Antigen
Alternative Name Thymidylate synthase (TYMS Antibody Abstract)
Background

Target Description: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Gene Symbol: TYMS///TS///OK///SW-cl.29

Gene ID 7298
UniProt P04818
Pathways Mitotic G1-G1/S Phases
Application Notes Prediluted format : incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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