TYMS antibody
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- Target See all TYMS Antibodies
- TYMS (Thymidylate Synthetase (TYMS))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TYMS antibody is un-conjugated
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Application
- Immunohistochemistry (IHC)
- Purpose
- Mouse anti-Human Thymidylate Synthase Antibody [IHC only]
- Specificity
- Cytoplasmic
- Purification
- Recombinant human Thymidylate synthase was used as the immunogen for this antibody.
- Immunogen
- Recombinant human Thymidylate synthase was used as the immunogen for this antibody.
- Top Product
- Discover our top product TYMS Primary Antibody
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anti-Thymidylate Synthetase (TYMS) (AA 36-313) antibody
TYMS Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 60-174) antibodyTYMS Reactivity: Human WB, IF, FACS, IHC, ISt, RIA, StM Host: Mouse Monoclonal TYMS-1884 unconjugated
anti-Thymidylate Synthetase (TYMS) antibodyTYMS Reactivity: Human WB, IF, IHC (p), IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 111-210) antibodyTYMS Reactivity: Human WB, IF, ELISA, IHC (p) Host: Mouse Monoclonal 3A1 unconjugated
anti-Thymidylate Synthetase (TYMS) antibodyTYMS Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 1D6 unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 265-294), (C-Term) antibodyTYMS Reactivity: Human WB, IF, FACS, IHC (p) Host: Rabbit Polyclonal RB20041 unconjugated
anti-Thymidylate Synthetase (TYMS) antibodyTYMS Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 5H8 unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 111-210) antibodyTYMS Reactivity: Human WB, ELISA, IHC (p), IP Host: Mouse Monoclonal 2B2 unconjugated
anti-Thymidylate Synthetase (TYMS) (AA 2-54) antibodyTYMS Reactivity: Human WB, IF, ELISA, IP Host: Rabbit Polyclonal unconjugated
anti-Thymidylate Synthetase (TYMS) antibodyTYMS Reactivity: Human, Mouse, Rat IF Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Prediluted format : incubate for 30 min at RT (2)
- Restrictions
- For Research Use only
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- Buffer
- Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Target
- TYMS (Thymidylate Synthetase (TYMS))
- Alternative Name
- Thymidylate synthase (TYMS Products)
- Target Type
- Viral Protein
- Background
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Target Description: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Gene Symbol: TYMS///TS///OK///SW-cl.29
- Gene ID
- 7298
- UniProt
- P04818
- Pathways
- Mitotic G1-G1/S Phases
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